Ernest Fraenkel

Professor, Department of Biological Engineering; Principal Investigator, Computer Science and Artificial Intelligence Laboratory

Ernest Fraenkel is a professor in MIT’s Department of Biological Engineering and a member of the Computer Science and Artificial Intelligence Laboratory and Broad Institute. His lab develops computational and experimental approaches to search for new therapeutic strategies for diseases. New experimental methods make it possible to measure cellular changes across the genome and proteome. They include genome-wide measurements of transcription, of protein-DNA interactions (ChIP-Seq), of genetic interactions, and of protein modifications. Each data source provides a narrow view of the cellular changes. However, by computationally integrating these data, the group can reconstruct signaling pathways and identify previously unrecognized regulatory mechanisms that help cause disease and may provide new approaches for treatment. Fraenkel was a postdoc at Harvard University and a Whitehead Fellow and Pfizer Computational Biology Fellow at the Whitehead Institute. He earned a BA in chemistry and physics from Harvard College, and a PhD in biology at MIT.