Connor Coley

Connor Coley is the Henri Slezynger (1957) Career Development Assistant Professor in MIT’s Department of Chemical Engineering. His research focuses on combining chemical engineering, computer science, and chemistry to advance the computer-aided discovery of new molecules. His lab develops platform technologies and workflows with relevance to drug discovery, chemical synthesis, and materials science. Coley earned a BS in chemical engineering from Caltech, and a PhD in chemical engineering from MIT.

Selected Publications

• Graff, D.E., Aldeghi, M., Morrone, J.A., Jordan, K.E., Pyzer-Knapp, E.O., Coley, C.W. (2022). Self-Focusing Virtual Screening with Active Design Space Pruning. Journal of Chemical Information and Modeling 2022 62 (16), 3854-3862 DOI: 10.1021/acs.jcim.2c00554
• Graff, D.E., Shakhnovicha, E.I., Connor W. Coley, C.W. (2021). Accelerating high-throughput virtual screening through molecular pool-based active learning. Chem. Sci., 2021,12, 7866-7881
• Gao, W., C. W., Coley. (2020) The Synthesizability of Molecules Proposed by Generative Models. Journal of Chemical Information and Modeling.

Media

• August 8, 2019: MIT News, Guided by AI, robotic platform automates molecule manufacture.
• November 28, 2018: Forbes, 30 Under 30 – Healthcare 2019.
• August 20, 208: Chemical & Engineering News, Machine-learning maestro is reprogramming the way chemists design drugs.